Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons[1][2][3][4].
Molecular Weight:
507.58
Purity:
98.89
CAS Number:
[1316755-16-4]
Formula:
C32H29NO5
Target:
Angiotensin Receptor
Application Notes:
Reference compound
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