gamma-Amanitin an ADC cytotoxin and isolated from the mushroom. gamma-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. gamma-Amanitin shows similar effects to alpha-Amanitin and beta-Amanitin. gamma-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. gamma-Amanitin is toxic to a variety of cells[1][2][3].
Molecular Weight:
902.97
Purity:
90
CAS Number:
[21150-23-2]
Formula:
C39H54N10O13S
Target:
ADC Payload,DNA/RNA Synthesis
Application Notes:
ADC Related
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