BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
Molecular Weight:
780.18
Purity:
95.01
CAS Number:
[2691796-83-3]
Formula:
C41H45Cl3N4O5
Target:
Target Protein Ligand-Linker Conjugates
Application Notes:
MCE Product type: Reference compound
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