PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 µM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1].
Molecular Weight:
966.80
Purity:
99.00
CAS Number:
[2488851-89-2]
Formula:
C40H53BrFN9O13
Target:
Indoleamine 2,3-Dioxygenase (IDO),PROTACs
Application Notes:
Reference compound
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