DS44960156 is a selective MTHFD2 inhibitor with moderate to low blood-brain barrier penetration (IC50=1.6 µM, Ki=1.23 µM). DS44960156 specifically binds to the active site of MTHFD2, disrupts redox homeostasis and blocks serine-mediated one-carbon metabolism, thereby increasing the NAD+/NADH ratio and ROS levels. DS44960156 not only effectively inhibits the proliferation of glioma cells, but also enhances the sensitivity of cells to glutamine starvation-induced death. DS44960156 binds to plasma proteins, shows no mutagenicity, carcinogenicity or acute oral toxicity, and serves as a research agent for glioblastoma multiforme and other cancers[1][2][3].
Molecular Weight:
349.34
Purity:
99.36
CAS Number:
[2361327-08-2]
Formula:
C20H15NO5
Target:
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Application Notes:
MCE Product type: Reference compound
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