CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-alpha and IL-1beta production activated by R-848 in THP-1 cells[1].
Molecular Weight:
569.21
Purity:
99.63
CAS Number:
[2471982-20-2]
Formula:
C21H11F7INO2
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound1
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