PF-06843195 is a highly selective PI3Kalpha inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kalpha and PI3Kdelta in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1].
Molecular Weight:
498.46
Purity:
98.12
CAS Number:
[2067281-51-8]
Formula:
C20H25F3N8O4
Target:
PI3K
Application Notes:
MCE Product type: Reference compound
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