Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1beta and IL-18 by human PBMCs with an IC50 of ~0.7 µM[1][2].
Molecular Weight:
509.00
Purity:
99.99
CAS Number:
[273404-37-8]
Formula:
C24H33ClN4O6
Target:
Caspase
Application Notes:
MCE Product type: Reference compound1
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