ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 µM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3].
Molecular Weight:
580.67
Purity:
99.72
CAS Number:
[960374-59-8]
Formula:
C31H40N4O7
Target:
Bacterial,HIV,Proteasome
Application Notes:
Reference compound
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