RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity[1].
Molecular Weight:
1778.13
Purity:
99.94
CAS Number:
[2382768-62-7]
Formula:
C93H136N10O24
Target:
mTOR
Application Notes:
MCE Product type: Reference compound
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