DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC50=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs[1].
Molecular Weight:
440.85
Purity:
98.22
CAS Number:
[2989908-08-7]
Formula:
C19H20ClF3N6O
Target:
Dihydroorotate Dehydrogenase,Parasite
Application Notes:
MCE Product type: Reference compound
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