Dolutegravir-d3 is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].
Molecular Weight:
422.40
Purity:
99.7
CAS Number:
[2673270-25-0]
Formula:
C20H16D3F2N3O5
Target:
HIV,HIV Integrase,Isotope-Labeled Compounds
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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