Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK alpha/beta, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38alpha MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1].
Molecular Weight:
420.53
Purity:
98.58
CAS Number:
[862505-00-8]
Formula:
C24H29FN6
Target:
Autophagy,p38 MAPK
Application Notes:
MCE Product type: Reference compound1
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