Tofersen, CAS [[2088232-70-4]]

Product Overview

• Article Name: Tofersen, CAS [[2088232-70-4]]
• Biozol Catalog Number: MCE-HY-132580
• Supplier Catalog Number: HY-132580
• Alternative Catalog Number: MCE-HY-132580-5MG,MCE-HY-132580-50MG,MCE-HY-132580-10MG,MCE-HY-132580-25MG,MCE-HY-132580-100MG,MCE-HY-132580-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: BIIB067, ISIS-SOD1Rx, ISIS 333611

Product Description

Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis[1][2][3][4][5][6][7][8][9].

Product Properties

• Molecular Weight: 7128.00
• Purity: 96.53
• CAS Number: [2088232-70-4]
• Formula: C230H317N72O123P19S15
• Target: SOD

Application Notes

• Application Notes: MCE Product type: Oligonucleotides