Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1)[1][2].
Molecular Weight:
16339.00
Purity:
98.77
CAS Number:
[1834610-13-7]
Formula:
C530H712F10N173O320P43S6
Target:
Glycolate Oxidase,Small Interfering RNA (siRNA)
Application Notes:
Oligonucleotides
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