MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 µM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis[1][2][3].
Molecular Weight:
475.62
Purity:
99.97
CAS Number:
[133407-82-6]
Formula:
C26H41N3O5
Target:
Apoptosis,Autophagy,Proteasome
Application Notes:
Reference compound
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