CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity.
Molecular Weight:
341.84
Purity:
99.69
CAS Number:
[885499-61-6]
Formula:
C18H20ClN5
Target:
Akt,Apoptosis,Autophagy
Application Notes:
MCE Product type: Reference compound1
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