AR-42 (HDAC-42, OSU-HDAC42) is a potent, orally bioavailable pan-HDAC inhibitor (IC50=16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis, and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines[1][2].
Molecular Weight:
312.36
Purity:
98.52
CAS Number:
[935881-37-1]
Formula:
C18H20N2O3
Target:
Apoptosis,Autophagy,HDAC
Application Notes:
MCE Product type: Reference compound
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