BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 µM-37.3 µM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].
Molecular Weight:
380.53
Purity:
98.10
CAS Number:
[1092443-52-1]
Formula:
C22H32N6
Target:
Apoptosis,CDK
Application Notes:
MCE Product type: Reference compound
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