ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on beta-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer[1][2][3][4][5][6][7][8].
Molecular Weight:
371.41
Purity:
99.40
CAS Number:
[141430-65-1]
Formula:
C18H17N3O4S
Target:
Apoptosis,Autophagy,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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