Selnoflast potassium (RO7486967 potassium), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast potassium is a potent inhibitor of IL-1beta release stimulated by NLRP3 activation in human Alzheimers disease (AD) monocyte-derived macrophages. Selnoflast potassium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3].
Formula:
C20H29N3O3S.xK
Target:
Interleukin Related,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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