Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 µM and 0.93 µM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK[1][2]. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells[3].
Molecular Weight:
474.96
Purity:
98.88
CAS Number:
[355025-24-0]
Formula:
C23H23ClN2O5S
Target:
LPL Receptor,YAP
Application Notes:
MCE Product type: Reference compound1
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