YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1].
Molecular Weight:
663.60
Purity:
98.07
CAS Number:
[2470908-79-1]
Formula:
C37H35BrN4O3
Target:
P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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