CFT-2718 is a selective CRBN-dependent BRD4 PROTAC degrader. CFT-2718 mediates rapid, selective BRD4 degradation, reduces total and phosphorylated Ser2 RPB1 levels, and reduces MYC protein levels. CFT-2718 can inhibit cancer cells proliferation and induce apoptosis. CFT-2718 reduces growth of lung cancer and pancreatic patient-derived xenograft models. CFT-2718 can be used for the research of cancer, such as small-cell lung cancer and pancreatic cancer[1].
Molecular Weight:
811.37
Formula:
C45H47ClN10O3
Target:
Apoptosis,c-Myc,Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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