nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express alpha7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimers disease[1].
Molecular Weight:
419.94
Purity:
98.35
CAS Number:
[1394371-75-5]
Formula:
C20H18ClNO3S2
Target:
nAChR
Application Notes:
MCE Product type: Reference compound
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