GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 µM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].
Molecular Weight:
386.76
Purity:
99.74
CAS Number:
[2304549-73-1]
Formula:
C16H14ClF3N4O2
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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