Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity[1][2].
Molecular Weight:
491.39
Purity:
99.41
CAS Number:
[781613-23-8]
Formula:
C24H25Cl2FN4O2
Target:
EGFR,Src,VEGFR
Application Notes:
MCE Product type: Reference compound
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