A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freunds adjuvant (HY-153808)-inflamed rat hind paws[1][2].
Molecular Weight:
425.42
CAS Number:
[1072921-02-8]
Formula:
C19H18F3N3O3S
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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