CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 25 µM).
Molecular Weight:
586.54
Purity:
99.41
Formula:
C27H29Cl2N7O2S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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