PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM[1][2].
Molecular Weight:
342.35
Purity:
97.02
CAS Number:
[878437-15-1]
Formula:
C17H18N4O4
Target:
PACAP Receptor
Application Notes:
MCE Product type: Reference compound
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