VSP-77 is an orally active PPARgamma agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARgamma at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD)-induced diabetic mouse models. VSP-77 can be used for the study of diabetes[1].
Molecular Weight:
298.81
CAS Number:
[1854008-12-0]
Formula:
C16H23ClO3
Target:
PPAR
Application Notes:
MCE Product type: Reference compound
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