12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].
Molecular Weight:
369.33
CAS Number:
[65281-77-8]
Formula:
C20H26Cl2O2
Target:
GABA Receptor,Potassium Channel
Application Notes:
MCE Product type: Reference compound
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