JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC50=85 ng/mL). The Ki values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders[1][2].
Molecular Weight:
458.41
Purity:
98.06
CAS Number:
[1628843-99-1]
Formula:
C22H18F4N6O
Target:
Orexin Receptor (OX Receptor)
Application Notes:
MCE Product type: Reference compound
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