N-Acetylserine is a complement pathway modulator targeting activated third complement protein (C3b) and an amino-terminal residue (an N-terminal acetylation modification group). N-Acetylserine reacts with the exposed thioester group of C3b via its hydroxyl group, thereby blocking the covalent binding of glycerol to this thioester group. N-Acetylserine widely exists in soluble proteins of mammalian cells (accounting for approximately 80% of such proteins). N-Acetylserine has a blocking property that prevents direct Edman sequencing of proteins, deblocking is achievable through trifluoroacetic acid-catalyzed NO acetyl migration followed by beta-elimination. N-Acetylserine is suitable for sequencing of proteins with N-terminal acetylserine modification[1][2].
Molecular Weight:
147.13
Purity:
98
CAS Number:
[16354-58-8]
Formula:
C5H9NO4
Target:
Complement System,Endogenous Metabolite
Application Notes:
MCE Product type: Reference compound
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