Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC50=0.012 µM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC50=0.16 µM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-alpha or IFN-gamma in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis[1][2][3].
Molecular Weight:
330.38
Purity:
98.03
CAS Number:
[108708-25-4]
Formula:
C18H22N2O4
Target:
Parasite,Prolyl Endopeptidase (PREP)
Application Notes:
MCE Product type: Peptides
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