Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research[1].
Molecular Weight:
356.77
Purity:
99.42
CAS Number:
[2101945-93-9]
Formula:
C16H16ClF3N4
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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