Avatrombopag (AKR-501) maleate is an orally active, non-peptide thrombopoietin receptor (TPO receptor) agonist (EC50: 3.3 nM). Avatrombopag maleate mimics the biological activity of TPO. Avatrombopag maleate increases platelet production by activating intracellular signaling systems and promotes the production of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A [1][2][3].
Molecular Weight:
765.73
Purity:
99.88
CAS Number:
[677007-74-8]
Formula:
C33H38Cl2N6O7S2
Target:
Cytochrome P450,ERK,STAT,Thrombopoietin Receptor
Application Notes:
MCE Product type: Reference compound
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