ALK-IN-1 is an orally active, blood-brain barrier-permeable ALK and EGFR inhibitor. ALK-IN-1 binds to and inhibits ALK kinase, ALK fusion proteins, and wild-type and mutant EGFR variants, thereby disrupting their corresponding signaling pathways. ALK-IN-1 can suppress the growth and proliferation of tumor cells and exhibits potential inhibitory activity against mutant EGFR. ALK-IN-1 can be used in the research of non-small-cell lung cancer[1][2].
Molecular Weight:
529.01
Purity:
99.94
CAS Number:
[1197958-12-5]
Formula:
C26H34ClN6O2P
Target:
Anaplastic lymphoma kinase (ALK),EGFR
Application Notes:
MCE Product type: Reference compound
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