KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC50 of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer[1].
Molecular Weight:
582.64
Purity:
98.45
CAS Number:
[2621928-43-4]
Formula:
C33H32F2N6O2
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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