JNJ-28312141 is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 exhibits anti-inflammatory activity in mouse arthritis model[1].
Molecular Weight:
460.57
CAS Number:
[885692-52-4]
Formula:
C26H32N6O2
Target:
c-Fms
Application Notes:
MCE Product type: Reference compound
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