Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 µM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity[1][2][3][4]. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 µM and and 0.8 µM for cowpox and monkeypox, respectively[5].
Molecular Weight:
444.48
Purity:
99.58
CAS Number:
[65271-80-9]
Formula:
C22H28N4O6
Target:
Apoptosis,Orthopoxvirus,PKC,Topoisomerase
Application Notes:
MCE Product type: Reference compound
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