JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2].
Molecular Weight:
277.75
Purity:
99.96
CAS Number:
[459168-41-3]
Formula:
C14H16ClN3O
Target:
Histamine Receptor
Application Notes:
MCE Product type: Reference compound
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