CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].
Molecular Weight:
316.35
Purity:
99.62
CAS Number:
[883050-24-6]
Formula:
C16H13FN2O2S
Target:
RGS Protein
Application Notes:
MCE Product type: Reference compound
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