Antiproliferative agent-54 (Compound 6z) is the inhibitor for multiple kinases, such as ABL WT, B-RAF, EGFR, HCK, LYN A and SRC with IC50 of 6-50 nM. Antiproliferative agent-54 inhibits proliferation of several cancer cell, inhibits HUVEC and HepG2, with EC50 of 34 and 38 nM. Antiproliferative agent-54 exhibits good pharmacokinetic characteristics in rats[1].
Molecular Weight:
562.54
CAS Number:
[1240322-54-6]
Formula:
C29H25F3N6O3
Target:
EGFR,Raf,Src,VEGFR
Application Notes:
MCE Product type: Reference compound1
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