Emavusertib is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib inhibits NF-kappaB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model
Molecular Weight:
491.50
Purity:
99.97
CAS Number:
[1801344-14-8]
Formula:
C24H25N7O5
Target:
Apoptosis,FLT3,IRAK,MyD88,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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