Emavusertib (hydrochloride), CAS [[2376399-42-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-135317B
Supplier Catalog Number:
HY-135317B
Alternative Catalog Number:
MCE-HY-135317B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
CA-4948 (hydrochloride)
Emavusertib hydrochloride (CA-4948 tosylate) is the hydrochloride salt form of Emavusertib (HY-135317). Emavusertib hydrochloride is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib hydrochloride inhibits NF-kappaB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib hydrochloride exhibits antitumor activity in mouse model[1][2][3].
Molecular Weight:
527.96
CAS Number:
[2376399-42-5]
Formula:
C24H26ClN7O5
Target:
Apoptosis,FLT3,IRAK,MyD88,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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