ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP-5862 is a weak time-dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].
Molecular Weight:
481.51
Purity:
98.32
CAS Number:
[2230757-47-6]
Formula:
C26H23N7O3
Target:
Btk,Cytochrome P450,Drug Metabolite
Application Notes:
MCE Product type: Reference compound
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