Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1)[1][2].
Molecular Weight:
252.18
Purity:
99.65
CAS Number:
[21919-05-1]
Formula:
C9H8N4O5
Target:
DNA Alkylator/Crosslinker,Quinone Reductase
Application Notes:
MCE Product type: Reference compound
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