AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing[1].
Molecular Weight:
552.52
CAS Number:
[1642113-59-4]
Formula:
C27H19F3N4O4S
Target:
Histamine Receptor,Sodium Channel
Application Notes:
MCE Product type: Reference compound1
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