RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification[1].
Molecular Weight:
818.00
Purity:
99.60
CAS Number:
[891198-31-5]
Formula:
C35H35BrClN4O10P
Target:
MMP
Application Notes:
MCE Product type: Reference compound1
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